Large skin infections, which need to ensure stable vital signs, require different treatments according to different causative agents, such as antibiotics, antivirals, antifungals, antileprosy drugs, and surgical treatments. 1. Antibiotics: mainly for large skin infections caused by bacterial infections. Commonly used drugs include erythromycin, penicillin, metronidazole, fusidic acid, etc. Sensitive drugs should be selected according to the results of drug sensitivity test. 2. Antiviral drugs: when the viral infection is clear, according to the type of virus, the use of drugs such as Penciclovir, Acyclovir, Imiquimod, Famciclovir and so on can be used as appropriate for medical treatment. 3. Antifungal drugs: If the infection is clearly fungal, antifungal drugs such as ketoconazole, fluconazole, itraconazole, terbinafine, etc. can be used for treatment. 4. Anti-leprosy drugs: If there is Mycobacterium leprae infection, then rifampicin, ampicillin and other drugs can be used for treatment. 5. Surgery: For large skin infections, when there is localized abscess formation, the skin can be surgically incised and drained. For large skin infections, the specific treatment also needs to be judged according to the actual situation of the patient, must follow the doctor’s instructions to use drugs, do not use without authorization.