The first choice of drugs for gastrointestinal bleeding should be based on the different causes of bleeding: 1. For gastrointestinal bleeding caused by esophagogastric fundic varices, vasoactive drugs such as growth inhibitors, octreotide, terlipressin and posterior pituitary hormone are preferred to reduce portal blood flow and lower portal pressure so as to stop bleeding. 2. For gastrointestinal bleeding caused by peptic ulcer, drugs that inhibit gastric acid secretion should be preferred to stop bleeding, such as PPI The PPI preparation should be preferred in case of hemorrhage, with pantoprazole, rabeprazole, omeprazole, estramiprazole, etc. administered intravenously. 3. If the lower and middle gastrointestinal bleeding is mostly due to inflammation and immune diseases, hemostasis should be achieved through anti-inflammatory, and anti-inflammatory drugs are preferred.