What causes heartburn in women needs to be determined by age, underlying disease, risk factors and the length of time the pain occurs, frequency of attacks, and accompanying symptoms. If the pain is long and frequent, accompanied by heavy sweating and pallor, you need to seek immediate medical attention. The location of the heart opening is generally referred to as the subxiphoid process. Pain located in this area has a variety of causes, including heart, lung, esophagus and other possibilities. Heart: The more common one is coronary heart disease. Episodic chest pain is characteristic of coronary artery disease. The typical pain site is behind the sternum. The nature of the pain is typically crush-like, mostly accompanied by significant chest tightness, and some patients have a sense of near death, often forcing the patient to stop activities immediately. Some patients have atypical symptoms, such as epigastric pain and subxiphoid discomfort. Symptom onset mostly exists as triggers, such as going upstairs, rapid walking, exertion, full meal, cold, emotional excitement, etc. The symptoms can be relieved by quiet rest. Lung: More common are lung infection, spontaneous pneumothorax, pleurisy, and lung cancer. Spontaneous pneumothorax often has tearing-like pain at the beginning. Lung cancer is persistent and severe pain. Pain due to pulmonary causes is mostly aggravated by breathing or coughing. Esophagus: Esophagitis and esophageal cancer can cause vague pain behind the sternum. It comes on or worsens during eating and can be relieved or disappeared by taking antacids and prokinetic drugs. Cardiac neurosis needs to be considered in those who fail to find organic pathology even after functional examination. Cardiac neurosis is most often seen in women between the ages of 20 and 40, especially during menopause. There is no pathological evidence of organic heart disease. Symptoms are varied, with typical very acute heart attack-like symptoms, including chest tightness, panic, breathlessness, and tightness in the precordial region. There are many causes of heartburn in women that require attention and timely medical attention to rule out the possibility of fatal disease.