Depression due to impotence can firstly be treated with selective type 5 phosphodiesterase inhibitor drugs such as sildenafil orally to treat impotence, and secondly, drugs such as fluoxetine need to be taken orally to treat depression. 1. Treatment of impotence. Impotence can be treated by oral sildenafil, tadalafil and other selective type 5 phosphodiesterase inhibitor drugs, but also local application of prostaglandin E1 and other drugs injected into the cavernous body of the penis for treatment. In addition, impotence can also be treated by surgery such as penile prosthesis implantation. 2. Treatment of depression. When depression occurs, attention should be paid to psychological treatment and change the bad lifestyle. Oral fluoxetine, paroxetine and other drugs as prescribed by the doctor for treatment. When men suffer from impotence, should be under the guidance of the doctor to apply drugs as well as other means of treatment for treatment, daily life should be relaxed mentality. If psychological problems occur, they should seek help from a psychiatrist.