Symptoms of low back pain, knee pain, and ankle pain can be considered as spondyloarthritis, also called seronegative spondyloarthritis, which is primarily a negative serum for rheumatoid factor and produces inflammation of the spine and joints, resulting in pain. This disease is often generalized and is not usually accompanied by pain, numbness, or loss of muscle strength in the lower extremities. If this condition occurs, it is recommended to go to the hospital for a detailed examination to clarify the diagnosis, which can also be treated with braking and rest and supportive symptomatic treatment. Patients should rest in bed and wear a lumbar brace for protection. Knee and ankle pads can also be worn to protect the knee and ankle joints to prevent injury. Oral anti-inflammatory and analgesic drugs such as fenbendazole and celecoxib can be taken to relieve pain in these areas. In addition, physical therapy can also be taken, including hot compresses, baking electricity and spectrum irradiation of painful areas. On the basis of a clear diagnosis, further treatments such as immunomodulatory agents and hormones can be taken, which are very specialized and cannot be treated at home by the patients themselves.