Shoulder pain is not necessarily a manifestation of liver cancer, but also seen in other diseases such as coronary heart disease, gallbladder disease and motor system disease. 1. Liver cancer, shoulder pain is rare in liver cancer, but when the tumor grows in the diaphragm, it will cause right shoulder pain due to the invasion of diaphragm. 2. Coronary heart disease, most common in left shoulder, patients with severe ischemia of myocardium will have pain in anterior thoracic region, and at the same time, they may have referred pain in left shoulder. 3. Gallbladder diseases, some gallbladder diseases such as acute cholecystitis, will appear in the right shoulder radiating pain. 4. Diseases of the locomotor system are common causes of shoulder pain, such as cervical spondylosis, frozen shoulder, subacromial impingement, shoulder dislocation and rheumatoid shoulder arthritis. If you have frequent shoulder pain, you should consult a doctor in time to clarify the cause of the pain and then take active treatment.