In clinical studies of psoriasis, we have found that some patients, especially women, experience changes in their condition during the endocrine change phase. As a result, researchers determined that there is a relationship between psoriasis and endocrine. After a long period of research and exploration, it was found that the appearance of psoriasis is related to a variety of hormones such as sex hormones and insulin. 1. Sex hormones and psoriasis Most female psoriasis patients will find their condition changing during pregnancy, menstruation and other changes in sex hormone secretion. Medical research has concluded that many hormone receptors, including sex hormones, can provide the material basis for immune regulation. Sex hormones can regulate antigen action which directly affects the ability of the immune response to work properly. In addition, sex hormones can also regulate the apoptosis of immune cells, which can prevent the immune response from becoming overactive and help the body to establish immune tolerance mechanisms. When the sex hormones change, it will easily lead to abnormal immune function of the body and induce psoriasis. 2, insulin and psoriasis Domestic and foreign research shows that there is a strong insulin resistance in psoriasis patients. Insulin is the only hormone in the body that can lower blood sugar and has an important role in the breakdown of sugar, fat metabolism and protein synthesis. Among them, patients with insulin resistance are prone to elevated blood glucose and prone to diabetes, etc. And diabetes can cause microangiopathy, making the skin blood supply insufficient, dermal tissue damage, inducing psoriasis. 3, adrenocorticotropic hormone and psoriasis Modern medicine has found that psoriasis patients generally have the condition of insufficient secretion of adrenocorticotropic hormone. Adrenocorticotropic hormone is a hormone secreted by the adrenal medullary cells that can regulate the central nervous system. It excites the nerves and increases the body’s resistance to the outside world. When the secretion of this hormone decreases, it will reduce the body’s ability to perceive external stimuli, weaken the immune system and lead to immune abnormalities, thus providing the possibility of psoriasis hair braid.