The primary causes of hepatic encephalopathy include severe viral hepatitis, severe toxic hepatitis, drug-related liver disease, acute fatty liver during pregnancy, all types of cirrhosis, post-portal-body vein shunt, primary liver cancer, and other end-stage diffuse liver disease, while hepatic encephalopathy occurs most frequently in patients with cirrhosis, accounting for about 70% of cases. There are many factors that induce hepatic encephalopathy, such as upper gastrointestinal bleeding, high protein diet, massive potassium diuresis, ascites discharge, use of sleeping, sedative and anesthetic drugs, constipation, uremia, infection or surgical trauma. So, what are the preventive measures for proximal coma? The following are preventive measures for proximal coma: 1. Prevention and correction of electrolyte and acid-base balance disorders. 2, control a variety of infections: such as intestinal infections, primary bacterial peritonitis, pneumonia, decubitus infection and sepsis, etc., is often an important cause of hepatic encephalopathy, anti-infective treatment should be given in a timely and reasonable manner. 3, careful use of sedatives, prohibit sulfur-containing, ammonia-containing drugs, strictly prohibit a large number of ascites, reduce surgery, trauma and excessive diuresis, etc., to get rid of medical factors. 4, constipation can be given lactulose, sorbitol, fruit guide, senna, rhubarb, sorbitol, magnesium sulfate and other oral as appropriate, can also be given open plug anal, if necessary, give clean enema. 5, timely treatment of gastrointestinal bleeding: the most fundamental way to prevent portal hypertension and upper gastrointestinal bleeding is to reduce portal hypertension or treatment of esophagogastric fundic varices, once the upper gastrointestinal bleeding should be given in a timely manner to stop bleeding, and timely removal of blood accumulation in the gastrointestinal tract.