Leukocyte esterase 1+ is correctly written clinically as leukocyte esterase (+), i.e., a positive leukocyte esterase test result. It is commonly seen in routine clinical urine tests or in female vaginal secretions, where the normal should be negative (-). However, regardless of the test, if the result suggests (+) it indicates that leukocytes are present in the specimen tested, but are not serious. Clinically, it is common for physiological reasons, for example, if a woman is tested during or around the time of her menstrual period, the result may indicate (+). In addition, it may also occur if she is taking medication or if there is contamination of the urine specimen. Leukocyte esterase (+) also suggests possible urinary tract infection and inflammation. If the test specimen suggests leukocyte esterase (+), it is usually considered to be bacteria from the genitourinary tract, which usually indicates the possibility that the organism has a urinary tract infection. However, leukocyte esterase (+) alone can not be a clear diagnosis, but also need to be combined with the patient’s symptoms and signs, as well as blood tests, urine bacteriology, imaging and other comprehensive judgment. If the test simply suggests that there is an abnormality, the patient has no other complications, usually, pay attention to maintain good hygiene habits, drink more water, more urination, usually do not need special treatment. However, if the urine routine or vaginal secretion examination of the presence of leukocyte esterase (+), and accompanied by urinary frequency, urinary urgency, urinary pain and other urinary tract irritation symptoms, and even back pain, fever and other discomforts, it is necessary to timely diagnosis, such as the existence of infection, need to be given a full course of anti-infective treatment, can be followed by the doctor’s instructions orally of oxfloxacin, norfloxacin, cefuroxime, and other medications, and do a good job to regular review, to make clear the recovery situation. Urinary tract infections are common in women and middle-aged and elderly men, including pyelonephritis, ureteritis, cystitis, urethritis, etc. Usually, the prognosis is good through timely treatment.