There are many causes of coughs, and coughs that are getting worse with medication may be the result of not accurately determining the primary cause of the cough, leading to the wrong choice of treatment. The more common clinical causes of cough are respiratory infectious diseases. Because the pathogens that cause the disease are different, it also affects the choice of drugs, for example, for Streptococcus pneumoniae infections preferred penicillins such as amoxicillin, mycoplasma infections preferred macrolides such as azithromycin, and so on. If the wrong antibiotic is applied, it may lead to disease progression and worsening of cough. Apart from this, other causes can also cause cough. For example, cough induced by angiotensin-converting enzyme inhibitors, commonly found in hypertensive patients, is caused by side effects of the drug, and can be improved after stopping the drug. If the cough is caused by allergy, it is necessary to stay away from allergens and give anti-allergy drugs such as cetirizine to relieve the symptoms. If the cough is simply treated, it will not improve the symptoms. Cough can be caused by many diseases, such as recurrent cough does not relieve or aggravate, it is recommended that patients seek medical advice in a timely manner, under the guidance of a professional doctor for treatment, do not use their own medication.