The common causes of dry skin on the corners of the mouth include keratitis, seborrheic dermatitis, contact dermatitis, etc., and need to target the cause of the disease, reasonable medication, such as the use of glucocorticosteroids, antihistamines and so on. 1. Keratitis: Infectious keratitis can be treated with topical antibacterial drugs, such as gentamycin ointment, etc.; severe bacterial infections, oral antibiotic treatment, such as erythromycin, doxycycline, etc.; traumatic keratitis, chlorhexidine acetate can be used to apply wet compresses, and topical rubbing of povidone-iodine treatment; perverse keratitis, antihistamines can be used to treat the condition, such as cetirizine and loratadine. 2. Seborrheic dermatitis: this disease can also lead to dry skin at the corners of the mouth. Generally for those who have fungal infections such as Malassezia infection, they can be treated with topical antifungal drugs, such as ketoconazole, econazole and so on. Inflammation is more serious, can be used topical glucocorticoid treatment, such as hydrocortisone cream, mometasone furoate ointment, etc.; itching is serious, but also oral antihistamine treatment, such as benadryl, cetirizine and so on. 3. Contact dermatitis: for subacute and chronic contact dermatitis, glucocorticoid therapy can be used externally, such as fluoride ointment, dexamethasone ointment, etc.; oral antihistamine therapy, such as chlortetracycline, cetirizine, etc.; if there is a secondary infection, the need for antibiotic therapy, such as cefradine, roxithromycin, etc.. It is recommended that patients go to a regular hospital, after a clear diagnosis, under the guidance of the doctor reasonable medication, not blindly self-medication.