Positive margin of radical prostatectomy for prostate cancer usually has a higher recurrence rate within 5 years, which is judged according to various reasons such as individual’s physical condition, severity of the disease, pathological staging of the treatment and nursing. Positive margin in radical prostatectomy means that there are still cancer cells in the resected section, which is prone to recurrence and metastasis in the later stage, so it is necessary to choose the suitable chemotherapeutic drugs under the guidance of the doctor in time, carry out systemic chemotherapy, and cooperate with local radiotherapy, to control the development of the disease, reduce the chances of metastasis and recurrence, alleviate the symptoms, and improve the quality of life of the patients. Keep a good mindset, do not have too much psychological pressure, usually pay attention to develop good living habits and dietary habits, eat more fresh fruits and vegetables, pay attention to rest, no smoking and no alcohol. Positive leading edge of radical prostatectomy for prostate cancer requires regular review to avoid delay.