Chronic fatigue syndrome treatment methods are as follows: 1, enhance self-care awareness: the World Health Organization pointed out that 60% of personal health and life expectancy depends on oneself, should establish a correct health concept, self-management of health and life; 2, reasonable exercise: exercise can make the brain produce morphine substances, so that people produce euphoria, effectively eliminate physical and mental fatigue, improve tension and anxiety; 3, reduce stress, maintain mental balance: regulate self-emotions, reduce stress, divert attention, cultivate hobbies, such as taijiquan, taiji sword, raising flowers, birds, fish and insects, qin, chess, calligraphy and painting; 4, good lifestyle: pay attention to a light diet, avoid high-calorie, high-fat diet, appropriate supplementation of vitamins and minerals, exercise should be gradual, in order not to fatigue; 5, regular physical examination: early detection of signs of disease, conditioning, transformation into healthy state.