Allergic dermatitis with severe itching at night requires oral administration of second-generation H1 receptor antagonists, such as levocetirizine hydrochloride and loratadine. It can also be combined with a generation of antihistamines, such as paracetamol and cyproheptadine, which have a strong sedative and antipruritic effect and are more effective for the severe itching that occurs at night. In addition to oral medications, you can also use topical compounded glyburide lotion, which has an astringent and anti-itch effect when applied externally to the skin. You can also apply topical hormonal creams, such as dinaide cream, mometasone furoate cream or topical compound camphor cream or peppermint cream with anti-itch effect. In addition, cold compresses can also be applied to the affected area to stop the itching effect. When itching occurs, you must avoid scrubbing the skin with alcohol and vinegar, and do not scratch with force to avoid scratching the skin to cause infection and aggravate the condition.