There are several cases of heel blistering as follows: the first case is herpetiform aspergillosis. The cause of this disease is not clear, mostly occurs in the elderly, in the heel of the foot appear thick-walled blisters, generally more than 0.5 centimeters in diameter, herpes relatively clear, and can be in all parts of the body can start. The treatment can be oral minocycline hydrochloride capsules and niacinamide tablets, and topical halomethasone ointment for treatment. The second condition is palmoplantar pustulosis, which is also a disease of unknown etiology and may be related to immune disorders and other factors. The third condition is eczema, mainly caused by allergies, in addition to small blisters, can also appear papules, accompanied by itching such a situation, can be treated with topical dinaide ointment.