Creatinine 135μmol/L suggests that blood creatinine is elevated, which is divided into physiologic and pathologic, and physiologic usually needs no treatment. Pathologic ones include acute renal failure and chronic renal failure, and different treatment programs are chosen according to different diseases. Physiological: creatinine may rise transiently after strenuous exercise or eating a large amount of meat, after resting or controlling diet, creatinine can return to normal, usually no treatment is needed. Pathologic: including acute renal failure and chronic renal failure, etc.. Acute renal failure is divided into pre-renal, renal and post-renal. Pre-renal such as circulating blood volume insufficiency, creatinine can usually return to normal after rehydration therapy. Post-renal, such as stones, creatinine usually returns to normal after treatment such as lithotripsy. In chronic renal failure, creatinine is usually difficult to recover, and the main purpose of treatment is to slow down the progression of renal function and prevent the deterioration of renal function. Treatment includes treatment of primary disease, nutritional therapy, antihypertensive control of proteinuria such as chlorthalidomide, enalapril, etc., and treatment of complications, etc. mainly. Patients with creatinine 135μmol/L are recommended to go to the hospital in time to clarify the cause of the disease and follow the doctor’s instructions for standardized treatment.