Fillings sealed 4 times more and more pain may be overuse of antiseptic drugs, root canal leakage and improper operation caused by the need to take observation, kill the nerve, medication and other treatments. 1. Excessive use of antiseptic drugs: when a large number of antiseptic drugs, the periapical soft tissues will form a stimulus, resulting in pain, generally no special treatment, such as drug metabolism can be relieved naturally, and can be closely observed during the period. 2. Root canal leakage: some patients are caused by the existence of root canal leakage, residual pulp fibers are more sensitive to drugs and thus wear pain, need to kill the nerve treatment, and then fillings to repair the tooth. 3. Improper operation: such as improper operation in the root canal preparation process, so that a large amount of blood infiltration of blood, internal pressure increases, thus causing pain, this need to promptly carry out hemostatic treatment, but also need to take cefamandole, cefuroxime and other antibiotic treatment. Pain after filling sealing medicine is an abnormal situation, need to follow the doctor’s guidance to take targeted treatment, so as to avoid continued aggravation of the condition. The use of drugs should follow the doctor’s instructions.