PD1-induced immune pneumonitis, i.e., PD-1 inhibitor-induced immune-mediated pneumonia, may present with fever, cough, sputum and other symptoms.
PD-1 is a programmed death protein-1, and PD-1 inhibitors can block the binding of PD-1 to its ligand, restoring T-cell activity and thus enhancing the patient’s immune response. Immune-mediated pneumonia is a complication of PD-1 inhibitor therapy and may result from its increased inflammatory response.
Patients may present with fever, cough, and sputum.
The development of pneumonia is usually poorly treated with antibiotics, and treatment with corticosteroids, such as methylprednisolone sodium succinate, may be an option.
Patients with immune pneumonia caused by PD1 are advised to go to regular hospitals as soon as possible for consultation and active treatment, avoiding blind self-medication.