Scrotal epidermal burning pain may be caused by non-disease factors such as inappropriate underwear, or it may be related to inflammation, scrotal eczema, genital herpes and other pathological factors. 1. Non-disease factors: such as wearing too tight underwear caused by the scrotum burning, pain and other discomforts, should be replaced in a timely manner with loose suitable underwear symptoms can be gradually relieved. 2. Pathologic factors: (1) Inflammation: such as epididymitis, scrotal inflammation, orchitis, etc., mostly caused by bacteria such as Staphylococcus aureus and other infections, which can cause pain and burning sensation in the epidermis of the scrotum, and the local skin can be accompanied by itching, redness and swelling and other symptoms. (2) Scrotal eczema: mostly seen in allergies, sweating and other people, can be manifested as scrotal burning, pain, itching, pimples and other symptoms. (3) Genital herpes: infection of herpes virus at the scrotum can cause herpes on the epidermis of the scrotum, and the blister rupture can cause symptoms such as ulceration of the epidermis of the scrotum, vesiculation, burning pain and so on. After excluding non-disease factors, it is recommended that patients with burning pain in the scrotum consult a doctor in time to clarify the cause of the burning pain and then actively treat it, so as not to delay the condition.