Colchicine should not be taken on an empty stomach because colchicine on an empty stomach will hurt your stomach and its side effects will increase. The most common side effects of colchicine are abdominal pain, diarrhea type of gastrointestinal reactions, and the side effects will be greater when taken on an empty stomach. For patients who cannot tolerate colchicine, it can be replaced with non-steroidal pain medication, such as erliximab or diclofenac sodium, for anti-inflammatory and pain relief. At the same time, colchicine in the process of taking, but also need to regularly monitor the liver function, renal function type of indicators, because colchicine may also have side effects of liver function, kidney function involvement.