Generally, acupuncture treats patients with persistent insomnia, which basically lasts for more than 6 months. Insomnia is mainly caused by the imbalance between yin and yang, and yang does not enter yin, that is, the insomnia caused by yang and yin failure. The main symptom of insomnia is difficulty in falling asleep or waking up easily after sleep, and some patients may have excessive dreams or even nightmares, which may lead to anxiety, irritability and depression. In the case of persistent insomnia, the insomnia lasts for a long time, some may be in a year or even two years, and the sleep state is always in the insomnia state. So if it is stubborn insomnia, the treatment time should be correspondingly long when acupuncture treatment. Acupuncture treatment is mainly to combine the patient’s physique, symptoms and condition to identify the acupuncture points selected to regulate the qi and blood of the internal organs of the whole body, thus promoting the balance of yin and yang, filling up the qi and blood, realizing the process of the body from movement to stillness, and prompting the body to enter a good sleep state. Since the symptoms of persistent insomnia are heavy, the course of treatment is relatively long. Generally, in clinical practice, in addition to acupuncture treatment for persistent insomnia, the selected acupoints are Baihui, Anmian, Shenmen and Neiguan, and acupoints can be added separately according to the differentiation and typing, such as Taichong, Fenglong, Zhonggui, and Feosanli. In this case, the clinical treatment must be combined with medication, which can make the symptoms of insomnia reduced.