Early pregnancy bleeding with blood clots may be caused by miscarriage, hyperemesis gravidarum, ectopic pregnancy and other diseases, such as miscarriage, the patient can follow the doctor’s instructions to use progesterone or progesterone vaginal preparation treatment; hyperemesis gravidarum, the patient can follow the doctor’s instructions to use fluorouracil injections and other medications to carry on the chemotherapy, and if necessary, can be taken to the surgical way of treatment; ectopic pregnancy, the choice of medication or surgical treatment, and so on. 1. Miscarriage: Miscarriage patients will have vaginal bleeding, lower abdominal pain and other symptoms, the patient can follow the doctor’s instructions to take oral progesterone tablets and other progesterone treatment, can also use progesterone vaginal preparation treatment. For the patients with indeterminate abortion, they can follow the doctor’s prescription of intravenous uterotonin to make the embryo discharged as soon as possible, and if there are residues in the uterine cavity, they can take the surgical way of treatment, such as hysterectomy, curettage and clamping. 2. Hyperemesis gravidarum: patients with hyperemesis gravidarum will have vaginal bleeding, pregnancy vomiting and other symptoms, patients can follow the doctor’s instructions to use fluorouracil injection, methotrexate injection, injectable actinomycin D and other drugs for chemotherapy; if necessary, they can be taken to clear the uterus, hysterectomy and other surgical procedures for treatment. 3. Ectopic pregnancy: patients with ectopic pregnancy will have abdominal pain, bleeding and other symptoms, patients can be prescribed methotrexate injection for treatment. For patients with more serious conditions, surgical treatments such as salpingo-oophorectomy can be taken. Therefore, when there are symptoms of bleeding with blood clots in the early stages of pregnancy, you should consult a doctor for examination, clarify the cause of the disease and then follow the doctor’s instructions for treatment.