Lymph nodes can be painful because when they grow large, they pull on the perineurium, which can cause a feeling of swelling and pain. Larger lymph nodes can press on the surrounding tissues and nerves, which can also cause pain. If there is obvious pain in the lymph nodes, you need to go to the hospital as soon as possible to complete the relevant examinations to clarify the cause of the disease, and you need to check the blood routine, C-reactive protein, ultrasound and so on. If it is considered to be caused by bacterial infection, antibiotics should be given for treatment. If it is considered to be caused by viral infection, antiviral drugs should be given to treat the disease, and at the same time, traditional Chinese medicine can be used to treat the disease, which is more effective. If allergy is considered to be the cause, it is necessary to get rid of the allergens and take desensitizing drugs for treatment at the same time. If malignant tumors are not considered to be the cause, puncture biopsy or excision biopsy of lymph nodes should be performed to clarify the nature of the disease.