Sophora ear granules can be used as adjuvant treatment after liver cancer resection, which can improve the symptoms of pain in liver area, abdominal distension, fatigue, etc., improve the quality of life, and inhibit recurrence with limited effect. The main ingredient of Sophora Ear Granules is Sophora Ear Clear Paste. Its manual points out that it has the effect of supporting the positive and consolidating the root, activating blood and eliminating symptoms. It is suitable for those who are weak in positive qi and stagnant in blood stasis, and those who are not suitable for surgery and chemotherapy for primary liver cancer as adjuvant therapy, which can improve the symptoms of pain in liver area, abdominal distension and fatigue, and improve the quality of life of patients. Domestic primary liver cancer guideline points out that Sophora Ear Granules and Huazhanin Combined Detoxification Granules can be used as adjuvant treatment after surgical resection of liver cancer. Some studies pointed out that locust ear granules can be used in postoperative liver cancer patients, which can prolong patients’ survival and reduce extrahepatic recurrence. Pharmacovigilance department has approved that Sophora Ear Granules and other traditional Chinese medicines can be used for adjuvant treatment after surgical resection. In conclusion, Sophora granules can be used as adjuvant treatment after hepatic cancer resection, but it needs to be carried out under professional doctor’s guidance, do not self-medication.