Slightly enlarged prostate with calcification detected by abdominal ultrasound in a 60-year-old is not necessarily cancer, but may also be prostatic hyperplasia, prostatitis, and requires further examination. Transurethral ultrasound in a 60-year-old patient found an enlarged prostate with calcification, which may be prostate cancer, but the accuracy of ultrasound is low, and the patient undergoes further examination, such as pelvic CTMR. Hematological tumor markers such as prostate-specific antigen are also needed for further diagnosis. The main symptoms of prostate cancer are difficulty in urination, hematuria, etc. A definitive diagnosis needs to be determined by pathology. However, patients also need to consider whether it is benign prostatic hyperplasia or prostatitis, because prostatic hyperplasia can also manifest as enlargement of the prostate with calcification, and the main symptom of patients is difficulty in urination to varying degrees. Pathologic biopsy is needed to determine the final means, and the general treatment is transurethral resection of the prostate. It is recommended to go to a regular hospital for a comprehensive assessment of the condition and follow the doctor’s instructions to avoid delaying the condition.