Low-grade CIN lesions refer to low-grade intraepithelial neoplasia of the cervix, which is commonly referred to as a pre-cancerous sign of the cervix and is used to distinguish high-grade cervical intraepithelial neoplasia CIN II from CIN III. Because of the low grade lesion, it is less likely to develop into cervical carcinoma and has a lower chance of developing cervical cancer. 60% of the lesions can subside on their own, while 30% of the lesions can progress to high grade cervical squamous intraepithelial neoplasia. For low-grade squamous intraepithelial neoplasia of the cervix, clinical observation can be done by first adjusting one’s resistance and regular outpatient follow-up examinations. In case of combined persistent HPV infection, active anti-HPV therapy is recommended and further treatment is required if further lesions are detected. For older patients, especially menopausal patients, with unsatisfactory colposcopic findings and CIN grade I lesions, cervical lipo or cold knife conization is recommended to further define the extent of the lesion.