The usefulness of taking safranin for diarrhea depends on what is causing the diarrhea. If it is clear that the diarrhea is caused by a bacterial infection, especially a mild diarrhea symptom caused by E. coli or E. dysenteriae, this is a particularly good time to take safranin. If the diarrhea is caused by other causes, such as non-infectious factors or viral infections, then taking safranin will not work. And for the treatment of diarrhea, safranin is not the first choice of medicine, but probiotics are generally preferred in clinical practice. Probiotics can regulate the disorder of intestinal flora and inhibit the reproduction of harmful bacteria, which can treat diarrhea. And probiotics have fewer side effects and can be used for both pregnant women and children. When the symptoms of diarrhea do not improve with probiotics, then consider combining with antibiotics or antibacterial Chinese medicine treatment. Huanglianxin is an antibacterial drug, but a traditional Chinese medicine, which is ideal for clear diarrhea caused by dysentery bacilli.