Fossa pain in the middle of the ribs may be caused by chronic gastritis, gastric ulcer, costochondritis, coronary artery disease, etc. Patients should consult a doctor in time to clarify the cause of the disease. 1. Chronic gastritis: If the pain in the middle of the ribs occurs in the lower part of the patient, accompanied by a feeling of fullness, dull pain, loss of appetite and other symptoms, it should be considered to be caused by chronic gastritis. Such people should look for the causes of gastritis and use omeprazole and bismuth pectin for treatment. 2. Gastric ulcer: The inner wall of the stomach is destroyed due to the damage of the mucous membrane of the stomach wall caused by the infection of Helicobacter pylori, long-term use of non-steroidal anti-inflammatory drugs and other factors, and the patient will have the symptoms of pain in the fossa in the middle of the two ribs, nausea, vomiting and so on. It can be treated with omeprazole, amoxicillin and bismuth triple drugs under the guidance of doctors. 3. costochondritis: the cartilage at the junction of sternum and ribs is more common in young adults, patients will have pain in the middle fossa of the ribs, which will be aggravated when coughing and exerting, and can be treated with ibuprofen and other medicines when the pain is serious. 4. Coronary heart disease: heart disease caused by narrowing or occlusion of the coronary artery lumen, patients will have pain in the middle of the two ribs, chest pressure, shortness of breath and other symptoms, nitroglycerin and other drugs can be used for treatment. All of the above drugs should be taken under the guidance of a doctor.