Puffiness in the cheeks and cheekbones below the eyes usually has the following factors: First, the most common factor is renal insufficiency. In patients with chronic renal insufficiency, facial puffiness is a common clinical symptom of puffiness caused by hypoproteinemia in the body. Low proteinemia is because the kidney function cannot effectively allow the body to absorb protein and filter it through the urine in the form of primary urine, it will appear as puffiness on the upper side of both cheeks under the eyes when there is hypoproteinemia. Second, common facial infections, for example, the face in the relatively developed capillary zone is particularly susceptible to bacterial infection, infection will appear subcutaneous cellulitis, in the presence of cellulitis will also appear under the eyes and cheeks puffy with red mouth, pain, joint dysfunction and other situations. Third, the face is also particularly susceptible to viral infections, which can lead to local facial nerve paralysis or facial neuritis, trigeminal neuralgia, where pain is intense and soft tissue swelling can occur in the cheeks under the eyes.