Some statins are taken at night because hydroxymethylglutaryl coenzyme A reductase activity is highest and cholesterol synthesis is most vigorous. Statin lipid-lowering drugs can competitively inhibit the activity of hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol synthesis in the body, to reduce the synthesis of cholesterol, due to the highest activity of hydroxymethylglutaryl coenzyme A reductase activity at night, part of the statin, such as simvastatin, pravastatin, etc., the drug has a shorter duration of action, so the general choice of the night to take. However, new types of statins such as Rosuvastatin and Atorvastatin can cover the whole day and are not restricted to be taken at night, and can also be taken in the morning. Specific medication needs to follow the doctor’s advice. Long-term oral statin drugs may have side effects such as elevated aminotransferases, muscle pain, myositis, etc. When the above symptoms occur, it is recommended to go to the hospital in a timely manner and follow the doctor’s instructions for treatment.