Creatinine 160μmol/L after kidney transplantation may be caused by transplantation rejection reaction, hydronephrosis, drug toxicity, etc. Treatment includes drug therapy and interventional therapy. 1. Transplant rejection reaction: after kidney transplantation, transplantation rejection reaction is easy to occur, transplantation rejection reaction will damage the kidney, cause renal decompensation, resulting in creatinine increase, can follow the doctor’s instructions to take immunosuppressant such as cyclophosphamide, azathioprine, etc., to inhibit immune rejection reaction and reduce renal damage. 2. Hydronephrosis: hydronephrosis may be caused by ureteric reflux after renal transplantation, hydronephrosis can also cause blood creatinine increase, we should get rid of the obstruction factors in time, and interventional therapy can be used if necessary. 3. Drug poisoning: the use of cefoperazone, gentamicin, amikacin, streptomycin and other renal damage after kidney transplantation will cause blood creatinine increase. The drugs that have damage to renal function should be stopped in time, and hormone or immunosuppressant therapy should be given according to the situation, the former includes prednisone, methylprednisolone, etc., and the latter includes cyclosporine and cyclophosphamide. Creatinine 160μmol/L after kidney transplantation should go to the hospital in time, complete the relevant examination, identify the cause, and standardize the treatment under the guidance of professional physicians.