Crohn’s disease is a common disease in clinical gastroenterology, which can be caused by a variety of reasons, has a long course, has a variety of clinical manifestations, is prone to various complications, and has a high recurrence rate after surgery, so it is generally treated conservatively. The treatment is limited and cannot be cured at present, and the treatment is only for symptom relief, mainly in the following aspects: traditional drug therapy including aminosalicylates (ASA), glucocorticoids (GCS), immunosuppressants and intestinal flora drugs; ASA and GCS are the preferred drugs for mild and moderately active CD, respectively; immunosuppressants can be used to relieve symptoms and reduce the recurrence rate after surgery; The intestinal flora drugs can balance the flora and reduce the release of pro-inflammatory factors. Biologic anti-tumor necrosis factor (TNF-α) studies confirm the efficacy of early step-down use. Novel small molecule drugs including Janus kinase inhibitors (JAK), phosphodiesterase 4 inhibitors (PDE4) and sphingosine-1- phosphate receptor modulators (SIP) reduce inflammatory factor production or inhibit inflammatory gene expression, and TCM treatment also needs to be promoted. It is also important to pay attention to the diet, to eat more high-calorie, easily digestible, less crumbly food, avoid cold, spicy and other stimulating foods, do not drink alcohol, tea, coffee, cool drinks, etc. Also supplement different kinds of vitamins and trace elements. Surgery is used when conservative treatment is ineffective or serious complications occur, the appropriate time has been reached and the patient can tolerate surgery.