The causes of hand numbness in sleep are physiological, diabetes, cerebrovascular disease, etc., which can be self-adjustment, rehabilitation therapy, drug treatment. 1. Self-adjustment: If you are carrying heavy objects, excessive use of hands and other circumstances, or sleep at night when the local area is subjected to prolonged pressure, there will be numbness in the hands, can be relieved after rest, do not need to take drugs. 2. Diabetes: long-term poor control of blood sugar, can cause peripheral neuropathy, resulting in peripheral sensory impairment of the hands and feet, hand numbness symptoms, can be aggravated at night, to control blood sugar at a normal level, you can use acarbose, glimepiride, insulin injection, with nutritive nerve medications, such as vitamin B1, methylcobalamin, and so on. 3. Cerebrovascular disease: hand numbness caused by ischemic cerebrovascular disease, need to use aspirin, atorvastatin and other anti-platelet aggregation, plaque stabilization drugs. Hand numbness at night, except physiological conditions, it is recommended to consult a doctor in a timely manner, a clear diagnosis and treatment, do not blindly self-medication.