Finger (toe) bone infarction is one of the symptoms of sickle cell anemia (crescentcellanaemia, sickle-cellanemia), which is a hereditary blood disorder and can also become a pure-hybrid sickle cell disease with clinical manifestations of varying degrees of hemolytic anemia and mild jaundice. Vascular occlusive crisis is its prominent manifestation, often with severe pain at the trunk and extremities, including visceral, bone, joint and muscle pain, especially metacarpal, epiphyseal and phalangeal (toe) infarcts are common, with infection, dehydration, hypoxia and acidosis as its triggers. Infection, dehydration, hypoxia and acidosis are the causes. Visceral and cerebrovascular infarcts present with corresponding signs and symptoms. Sickle cell anemia is a hereditary disease, and its prevention should pay attention to the following points: 1. Genetic counseling Through the patient’s family survey, laboratory tests and combined with clinical characteristics, we can make a correct diagnosis of the patient’s disease, determine whether it is a genetic disease, and determine whether it is generated by a new mutation or inherited; secondly, we should determine the mode of inheritance; finally, we should propose countermeasures and solutions. 2, prenatal diagnosis Certain hereditary diseases can be diagnosed during pregnancy, such as chromosomal diseases, neural tube defects (anencephaly, cerebrospinal bulge, etc.). Some metabolic diseases and sex-linked genetic diseases can be checked for chromosomes by taking chorionic villi in early pregnancy, or amniotic fluid examination, including amniotic fluid chromosome examination and other biochemical examinations, etc., in 16-20 weeks of gestation, and B ultrasound can also be used to examine abnormal fetuses and terminate pregnancy in time for detected sick fetuses. 3, pre-marital male and female heterozygous examination recessive genetic disease heterozygous with disease-causing genes but does not develop, but two heterozygous marriage may give birth to a pure heterozygous disease infant, and this recessive genetic disease is usually high incidence of consanguineous marriage. Therefore, the prohibition of consanguineous marriages can also serve the purpose of prevention.