There are a lot of differences between lipoma and lymph nodes. Lipoma is caused by diseases and lymph nodes are normal physiological tissues. 1. Lipoma: Lipoma is a kind of benign tumor, which is formed by abnormal proliferation and differentiation of normal adipose tissue. There are also special types of lipoma, such as variant lipoma, infiltrative lipoma, etc. Generally, benign lipoma doesn’t need to be worried, and attention should be paid to the observation, if there are symptoms of pressure, affecting aesthetics or accelerated growth, and there is a risk of malignant transformation, timely surgical treatment is needed. 2. Lymph nodes: lymph nodes are normal physiological tissues, enlarged lymph nodes are common in lymphadenitis, lymphatic tuberculosis, lymphoma, malignant tumor metastasis and so on. If there are abnormalities in lymph nodes, you should go to the hospital for examination in time to clarify the cause of the disease. Lipoma or lymph node abnormality is found, you need to go to the hospital in time for examination and diagnosis.