After eating cephalosporins, it is best not to rub alcohol, if the wound is large, the use of alcohol more, there may be alcohol into the blood and lead to disulfiram poisoning reaction. Disulfiram reaction is mainly cephalosporins affect the decomposition of alcohol metabolites acetaldehyde, making acetaldehyde accumulation, red face, nausea and vomiting, dizziness, headache and other alcohol poisoning-like symptoms, serious cases may be life-threatening. Usually the toxic reaction occurs in the cephalosporins and alcohol coexist in the body within a few minutes to an hour, the severity of the toxic reaction is closely related to the dose of cephalosporins, the dose of alcohol into the blood, and so on. If the surface of the limb is non-invasive and is sterilized with alcohol, usually not enough alcohol enters the body to cause a disulfiram reaction. However, for safety reasons, it is best to avoid internal or external use of alcohol-containing substances. If uncomfortable symptoms occur that do not resolve on their own. It is recommended to seek medical attention as soon as possible to see if treatment such as oxygen or gastric lavage is needed under the guidance of a doctor.