Lennox-Gastaut syndrome is a seizure type of epilepsy syndrome that occurs in children aged 1-8 years, and rarely can appear in adolescents, with the coexistence of multiple seizure forms such as compulsive seizures, atonic seizures, myoclonic seizures, atypical akathisia seizures, and generalized tonic-clonic seizures. The syndrome has three main features, including mental retardation, an EEG with spike and slow complex waves (1-2.5 Hz), and a fast rhythm of 10 Hz in sleep. The disease is prone to persistent status epilepticus and is treated with sodium valproate, topiramate and lamotrigine, with a poor prognosis in most children.