Toe pain at night may have the following reasons: first, gout, when gout involves the toe joints, there can be one and more toe pain, can be accompanied by skin redness and swelling, as well as elevated skin temperature, the serious cases will have gout stone formation, blood uric acid tests, as well as foot X-ray film examination, for early diagnosis and early treatment. Second, rheumatism and rheumatoid, when rheumatism, rheumatoid, can also appear at night when the toe pain symptoms, blood tests, as well as foot X-ray examination, for diagnosis and treatment. Third, tumors or infections, when the toe has tuberculosis or tumors, can also appear at night when the symptoms of toe pain in bed, to carry out the relevant foot nuclear magnetic, X-ray examination, as well as blood tests, to carry out early diagnosis and early treatment.