The development and evolution of the blocker has revolutionized the treatment of congenital heart disease. Through the interventional route, the trauma caused to patients due to traditional open-heart surgery has been significantly reduced and the great risk of surgical procedures has been reduced; the use of blockers, through the interventional approach, makes the procedure simple, low-traumatic, reduces the chance of infection, the patient recovers quickly after surgery, and the treatment effect is remarkable. The research and clinical application of blockers began in the 1960s, matured in the 1980s, and entered its heyday in the 1990s. The use of occluders can repair patent ductus arteriosus (PDA), atrial septal defect (ASD), ventricular septal defect (VSD), patent foramen ovale (PFO), etc. and restore normal heart function. The interventional closure of congenital heart disease is performed by puncturing the femoral vein or femoral artery, inserting a photographic catheter into the heart to detect the size of the defect, and then selecting a blocker of the same type made of special material and sending it through the catheter to block the defect. The entire procedure usually takes about 1 hour, with 10 to 30 ml of blood loss, and the patient can be on the floor 6 to 10 hours after the procedure. Even if the occlusion is unsuccessful due to the special location, the catheter can be withdrawn without causing any damage to the patient. The blocker is basically covered by new endothelial cells 3 months after surgery, and the patient can go on with his normal life and work.