There is no harm in taking antihypertensive drugs four hours in advance. Human blood pressure has two spoon-shaped peaks, antihypertensive drugs are best taken about 1-2 hours before the blood pressure reaches its peak, to maximize the stability of blood pressure control. The first peak value of blood pressure is about 2 hours after waking up in the morning, around 9:00 a.m., and the second peak value is around 8:00 p.m. It is recommended to take antihypertensive medication at 7-8:00 a.m. or 6-7:00 p.m. Commonly used antihypertensive drugs in clinical practice include calcium antagonists, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor antagonists (ARBs), beta-blockers, and diuretics. It is recommended to choose the appropriate drug according to the patient’s age, characteristics of hypertension and so on. Controlled-release tablets or extended-release tablets of antihypertensive drugs are usually taken once a day, which is recommended to be taken in the morning before meals, and short-acting antihypertensive drugs are usually taken twice a day, which can be taken before breakfast and dinner. If taken four hours in advance, it also has the function of controlling blood pressure, but it may be because the distance between it and the peak of human blood pressure is relatively long, and it is easy to have small fluctuations in blood pressure within a day, which is not conducive to the stabilization of blood pressure. Patients with high blood pressure are recommended to use medication under the guidance of a doctor in a scientific and standardized manner, do not miss doses, do not casually change the dosage and type of medication, and regularly monitor blood pressure.