The most common causes of thick ankles are congenital factors, ankle sprains, kidney diseases, etc. If accompanied by obvious uncomfortable symptoms, it is recommended to seek medical treatment in time. 1. Congenital factors: Some people are born with strong bones, which makes their ankles look thicker, and usually there are no uncomfortable symptoms. 2. Ankle sprain: If the ankle is sprained accidentally, causing local muscle and ligament strains, edema will be formed at the ankle, which will show thick ankles. 3. Kidney disease: if you suffer from kidney disease, such as nephritic edema, nephropathic edema, etc., it is possible to form edema at the ankle, and then show thick ankle. Causes of ankle thickness are more reasons, may also be related to liver disease, cardiac insufficiency, poor blood circulation in the lower limbs, etc. It is recommended to go to the hospital in time by the doctor to identify the cause of the disease, targeted treatment.