Intestinal epithelial chemotaxis is a surgical procedure in which abnormally chemotaxed tissue in the gastric mucosa is removed endoscopically. Hyperplasia refers to the transformation of one mature cell type of differentiation into another mature cell type, and is a change made by the organism to adapt to external stimuli. Intestinal epithelial metaplasia occurs mostly in the gastric mucosa, refers to the normal gastric mucosal epithelium, the surrounding glands metaplasia for other epithelial tissues, metaplasia into tissues similar to intestinal epithelial and glandular tissues. Intestinal epithelial hyperplasia is a kind of precancerous lesion caused by chronic inflammation resulting in long-term damage to gastric mucosa and its surrounding glands due to various factors. Intestinal epithelialized growths are classified into type I, type II and type III, among which type III intestinal epithelialized growths have a higher risk of transforming into gastric cancer, which is mostly treated by surgery to prevent the occurrence of gastric cancer. To prevent gastric cancer, surgery is often adopted. Surgery is performed under endoscopy, and the main modes include mucosal resection, argon knife treatment, laser treatment, high-frequency electrosurgery, etc. Different surgical modes are chosen according to the patient’s condition, and the resection of diseased tissues can effectively improve the prognosis. In order to prevent the occurrence of gastric cancer, endoscopic monitoring is advocated every 3 years for high-risk patients such as those with extensive atrophic gastritis and gastric mucosal intestinal epithelial hyperplasia. Patients with intestinal epithelialized gastric mucosa should have regular follow-up and follow the doctor’s instructions.