Children’s closed mouth acne, also known as closed acne, is mainly caused by excessive secretion of sebaceous glands in hair follicles leading to blockage of the follicular opening, and can be intervened through general treatment, medication, physical therapy and other treatments. 1. General treatment: keep the affected area clean and dry, avoid scratching the affected area directly with hands; eat a light diet, avoid spicy stimulation, cold and greasy diet. 2. Medication: patients can apply Vitamin A acid cream, benzoyl peroxide and other medications under the guidance of the doctor for treatment, after the use of medication may appear burning pain, tingling and other adverse reactions, should be promptly discontinued, and seek medical attention. 3. Physical therapy: such as photodynamic therapy, laser therapy, etc., which can be applied with other modalities and can also be used for the treatment of acne sequelae. 4. Other treatments: such as the application of acne squeezer to squeeze out the acne content, followed by the use of drugs, can play a better role. Children with closed acne should go to a dermatologist and be treated with a program developed by a specialist.