Sore arms and legs during sleep may be caused by factors such as fatigue, cervical spondylosis, and deep vein thrombosis of the upper extremities. 1. Exhaustion: heavy physical labor and upper extremity exercise before going to bed can lead to a large accumulation of lactic acid in the muscles of the upper extremities, resulting in the symptoms of soreness and discomfort in the arms during sleep. 2. Cervical spondylosis: this disease is related to cervical vertebrae degeneration, injury and other factors, and the compression of the nerves will lead to upper extremity soreness, heaviness, weakness and other symptoms, and the above symptoms may occur during sleep. 3. Upper extremity deep vein thrombosis: the disease is related to upper extremity vascular compression, venous injury and other factors, venous reflux in the hands and feet, which will lead to swelling of the upper extremities, the patient may feel sore and swollen arms while sleeping. When sleeping with soreness and swelling of the arms, you can go to the hospital in time and get relevant treatment under the guidance of the physician.