Cephalosporins and penicillins are less irritating to the gastric mucosa. The layer of gastric mucosa attached to the stomach wall is able to secrete digestive juices by itself and also has the function of protecting the stomach wall, but there are some drugs with certain irritation, which can cause irritation to the gastric mucosa and even cause pain after entering the digestive system. For people with damage to the gastric mucosa, when using drugs, it is best to try to choose drugs such as cephalosporin and penicillin to reduce the damage to the gastric mucosa, which include cefadroxil, cefoperazone, cefepime, amoxicillin, ampicillin, piperacillin and so on. These drugs are not only less toxic and have good antibacterial effect, which can reduce the irritation caused by the drugs to the digestive system after taking them. When taking drugs that have an irritating effect on the gastric mucosa, it is best to take them after a meal so that the irritation of the drug can be reduced and the effectiveness of the drug can be brought into play at the same time.