Late-night coughing requires close attention to whether the patient has a respiratory infection or a respiratory allergic disease. If it is a respiratory infection, we need to be alert to the possibility of tuberculosis infection. Tuberculosis infection is mainly manifested by night coughing, coughing up sputum, hot flashes, night sweats, body wasting, sometimes accompanied by blood in the sputum. If the patient is combined with diabetes mellitus, it is more important to be alert to whether the shadow on the lung is tuberculosis infection. Chest high-resolution CT, sputum test for tuberculosis antacid bacilli and other tests are needed to further exclude. Late-night cough if respiratory allergic diseases, need to pay attention to whether the patient has allergic rhinitis, allergic bronchial asthma, these two types of diseases in the night due to vagus nerve excitation, bronchoconstriction, caused by the airway reactivity increases, induced by the cough aggravation, need to be given to anti-inflammatory, anti-allergic treatment.