There is no uniform standard for the time to resolve pathological jaundice, and it cannot be generalized and is related to the specific cause of pathological jaundice. Generally, the causes of pathological jaundice can be divided into two types: one is due to infectious factors, such as septic cholangitis, acute pancreatitis, viral hepatitis, etc. The other is due to non-infectious causes of jaundice, such as bilirubin metabolism dysfunction, pancreatic cancer, heart failure, etc. Under normal circumstances, for pathological jaundice caused by infectious etiology, it can subside after about 2 weeks of standardized treatment. However, if the jaundice is caused by a non-infectious etiology, a comprehensive judgment is needed in conjunction with the patient’s actual condition and treatment modality. During the treatment period, the patient’s mental condition should be observed more frequently. If there are symptoms such as mental depression, limb convulsions, or high fever convulsions, the patient needs to be sent to the hospital emergency room or relevant departments for timely treatment as soon as possible to avoid missing the best time for treatment.