Separation of nail flesh and nail edge may be caused by trauma, gray nail and other factors, which can be treated by using iodine povidic disinfection under doctor’s guidance and with medication or surgery. 1. Trauma: In daily life, when the nail surface is impacted, it may cause the nail surface to fall off and the nail flesh and nail edge to separate. It is recommended to consult a doctor for examination in a timely manner and use gauze for bandaging after sterilizing with iodine povidone under the guidance of a doctor. 2. Gray nail: usually due to the skin fungus invasion of the nail plate or nail bed caused by nail lesions, if not treated in time, may lead to local tissue necrosis, resulting in the phenomenon of nail flesh and nail edge separation. Patients can be treated with drugs such as amorolfine and cyclopamine under the guidance of a doctor. For more severe cases, nail debridement may be used. When the nail flesh and nail edge are separated, it is recommended to consult a doctor in time to avoid delaying the condition and leading to adverse consequences.