The role of liver cancer treatment with stem cells cannot be determined, and stem cell treatment for liver cancer is not a common treatment method. Patients with liver cancer generally do not need stem cell therapy. Treatment methods for liver cancer generally include surgical resection, interventional therapy, liver transplantation, radiotherapy, chemotherapy, targeted drug therapy, immunotherapy and so on. If patients cannot undergo surgery, they can only use other treatment modalities or comprehensive treatment, and they have to choose appropriate treatment methods according to the stage of liver cancer, examination results and specific conditions. There are relatively few seminars on stem cell therapy for liver cancer, and with the development of medicine, the scope of stem cell therapy may be expanded. Liver cancer patients should not blindly use stem cell therapy, but should formulate individualized treatment plan under the guidance of physicians in regular hospitals according to their conditions and follow standardized treatment to avoid adverse results.