Rough skin keratinization may be related to conditions such as perifollicular keratosis, ichthyosis, psoriasis, etc. Depending on the cause of the condition, it can be relieved by topical moisturizing medication, glucocorticoid medication, and Vitamin A acid medication. 1. Keratosis pilaris: generally no special treatment is needed, if necessary, it can be treated with cod liver oil ointment, salicylic acid, retinoic acid ointment and other drugs. 2. Ichthyosis: the skin can be kept moist by applying topical moisturizer. If necessary, apply urea cream, petroleum jelly and other drugs to relieve, retinoic acid topical preparation, etc. can improve keratinization, and glucocorticoids can increase the efficacy of the combination. 3. Psoriasis: Vitamin D3 derivatives such as Calcipotriol and calcium-regulated phosphatase inhibitors such as Tacrolimus ointment can be applied. If necessary, immunosuppressants such as azathioprine can be used. Due to the cause of the disease is more, the patient should consult the doctor in time, do a systematic examination, strictly comply with the doctor’s instructions for treatment, not indiscriminate use of drugs.